Location and Contact Information
The Douglas laboratory investigates signaling pathways mediating vascular development early in pregnancy during endometrial decidualization and placenta formation. We use conditional genetic mouse models to study the role of Notch and Vascular Endothelial Growth Factor in endothelial cell and trophoblast interactions during early pregnancy. Information gained from our murine genetic studies is used to understand endometrial function, infertility, and adverse pregnancy outcomes such as early miscarriages, fetal growth restriction, and preeclampsia. Our research approach consists of testing animal models while simultaneously seeking to validate these animal models against human disorders of pregnancy. This approach has the potential to make significant contributions to understanding the mechanisms underlying uterine vascular development and differentiation during embryo implantation, placenta formation, and preeclampsia.
Dex-Ann Brown-Grant, PhD
Postdoctoral Research Scientist
Senior Research Worker