Carrie Shawber

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Overview

Carrie Shawber is an Associate Professor of Reproductive Sciences (in Obstetrics/Gynecology and Surgery) at the Columbia University Medical Center. Dr. Shawber received her BS in Biology and PhD in Molecular Biology from University of California, Los Angeles. After completing her graduate studies on Mammalian Notch Signaling, Dr. Shawber trained as a postdoctoral research fellow at Weill Cornell Medical College in Cancer Genetics and Epigenetics and Columbia University in Vascular Biology. Her studies of embryonic lymphatic development and lymphatic anomalies have received funding from the Department of Defense, National Cancer Institute, and National Institute of Biomedical Imaging and Bioengineering, as well as private foundations. Dr. Shawber’s laboratory is currently funded by the National Institute of Diabetes and Digestive and Kidney Diseases, and the Department of Defense Medical Research Program.

Academic Appointments

  • Associate Professor of Reproductive Sciences (in Obstetrics/Gynecology and Surgery) at the Columbia University Medical Center

Credentials & Experience

Honors & Awards

  • NIH/NIDDK Mentored Research Scientist Development Award, 2006-2010
  • LRF-Andrew Moisoff Young Investigator Poster Award Recognition, Molecular Mechanisms in Lymphatic Function and Disease, Gordon Research Conference, 2004
  • Department of Defense Breast Cancer Postdoctoral Fellowship, 2003-2006
  • NIH/NCI Molecular and Developmental Biology of Cancer Training Grant (Columbia University), 2002-2003
  • NIH, Biotechnology Training Grant (UCLA), 1996-1998
  • Paul Boyer Fellowship, Molecular Biology Institute (UCLA), 1995
  • Second place: Poster Competition, Society for Developmental Biology 54th Annual Symposium, 1995

Research

By understanding how the blood and lymphatic vasculature develop, we gain insights into vascular pathologies that contribute to human diseases, such as atherosclerosis, hypertension, fat disorders, stroke, Alzheimer’s, cancer metastasis and immune escape, and much more.

The Shawber laboratory is interested in understanding developmental and pathological lymphatic vascular biology. We use conditional genetic mouse models to study the role of Notch, MMPs, and RERE in lymphatic endothelial specification, remodeling, and homeostasis with a focus on the digestive track and the skin. Information gained from our murine genetic studies is used to understand human pathological lymphatic disorders and diseases, such as Down syndrome, Turner syndrome, lymphatic malformations, congenital chylothoraxes, and generalized lymphatic anomalies. In collaboration with Dr. June Wu, a Plastic Surgeon at CUMC, we developed a Basic and Translational Vascular Anomalies Research Program in January 2014 with the goals to characterize and identify the genetic and molecular causes of blood and lymphatic vascular anomalies/disorders/diseases, as well as improve diagnosis via new imaging methodologies and identify optimal treatment options for patients.

Research Interests

  • Lymphatic Congenital Defects
  • Lymphatic Vascular Development
  • Notch, MMP
  • Vascular anomalies

Grants

GENETIC CAUSES AND THERAPEUTIC INTERVENTIONS IN VASCULAR MALFORMATIONS (DOD/PRMRP-IIRA)

2019-2022

IDENTIFICATION AND CHARACTERIZATION OF THE GENETIC CAUSES OF LYMPHATIC ANOMALIES (NIH/NICHD)

2017-2019

NOTCH FUNCTION IN POSTNATAL INTESTINAL AND MESENTERIC LYMPHATICS (NIH/NIDDK)

2017-2022

IDENTIFICATION OF THE GENETIC CAUSES OF GENERALIZED LYMPHATIC ANOMALIES (MDBR)

2017

CHARACTERIZATION AND THERAPEUTIC TARGETING OF LYMPHATIC DYSFUNCTION IN CONGENITAL CHYLOTHORAX (Irving Institute for Clinical and Translational Research)

2014

CONCURRENT ULTRASOUND & MOLECULAR EVALUATION OF A LYMPHATIC MALFORMATION MODEL (NIH/NIBIB)

2013-2016

NOTCH SIGNALING IN LYMPHAGIOGENESIS (NIH/NCI)

2009-2015

NOTCH AND INSULIN: SIGNALING INTERACTING IN ADIPOGENESIS AND ANGIOGENESIS (NIH/NIDDK)

2006-2010

Selected Publications

For a complete list of publications, please visit the National Library of Medicine.

  • Shakoor, A.*, Wu, J.K.*, Muley, A., Kitajewski, C., McCarron, J.D., Shapiro-Franklin, N., Corda, R., Chrisomalis-Dring, S., Chai, P.J., and Shawber, C.J. (2021) Lymphatic endothelial cell defects in congenital cardiac patients with postoperative chylothorax. Journal of Vascular Anomalies (*Co-first authorship; In Press).
  • Schonning, M., Koh, S., Sun, R., Richter, G. T., Edwards, A. K., Shawber, C.J., and Wu, J. K. (2021) Venous malformation endothelium is improperly specified and hyperproliferative. PLoS One. May 27;16(5):e0252342.
  • Lee, J.C., Modiri, O., England, R.W., Shawber, C.J., and Wu, J.K.,MD. (2021) Propranolol Therapy in Infantile Hemangioma: It is Not Just About the Beta. Plast Reconstr Surg. 2021 Apr 1;147(4):875-885.
  • Gomez-Acevedo, H., Stone, A., Dai, Y., Strub, G., Shawber, C., Wu, J.K., and Richter, G.T. (2020) Identification of putative biomarkers for Infantile Hemangiomas and Propranolol treatment via data integration. Scientific Reports. Feb 24;10(1):3261.
  • Davis, R.B., Pahl, K., Datto, N.C., Smith, S.V., Shawber, C., Caron, K.M., and Blatt, J. (2018) Notch signaling pathway is a potential therapeutic target for extracranial vascular malformations. Scientific Reports. 8:17987.
  • Edwards, A.K., Glithero, K., Grzesik, P., Kitajewski, A.A., Munabi, N.C.O., Hardy, K., Tan, Q.K., Schonning, M., Kangsamaksin, T., Kitajewski, J.K., Shawber, C.J.†, and Wu, J.K†. (2017) Requirement for NOTCH3 in stem cell to vascular smooth muscle cell transition in infantile hemangioma. JCI Insights. 2(21). pii: 93764 (†Co-senior authorship)
  • *Wu, J.K., Hooper, E.D., Laifer-Narin, S.L., Simpson, L.L., Kandel, J.J. and Shawber, C.J. (2016) Initial experience with propranolol treatment of lymphatic anomalies: A case series. Pediatrics. 138:e20154545.
  • Munabi, N.C.O, England R.W., Edwards, A.K., Kitajewski, A.A., Tan, Q.K., Weinstein, A., Kung, J.E., Wilcox, M., Kitajewski, J.K., Shawber, C.J., and Wu, J.K. (2015) Propranolol targets hemangioma stem cells via cAMP and MAPK regulation. Stem Cell Translation Medicine. 5:45-55.
  • *Wu, J.K., Kitajewski, C., Reiley, M., Andrews, J.P., Thirumoorthi, A., Wong, A., Keung, C.H., Monteagudo, J., Kitajewski, A., Sastra, S., Behr, G., Kandel, J.J.†, and Shawber, C.J.† (2015) Aberrant Lymphatic endothelial progenitor cells in lymphatic malformation development. PLoS One. 10:e0117352. (†Co-senior authorship)
  • England, R. W., Hardy, K.L., Kitajewski, A.M., Wong, A., Kitajewski, J., Shawber, C.J., and Wu, J. K. (2014) Propranolol promotes accelerated and dysregulated adipogenesis in hemangioma stem cells. Annals of Plastic Surgery. 73 Suppl 1:S119-24.
  • *Murtomaki, A., Uh, M.K., Kitajewski, C., Zhao, J., Nagasaki, T., Shawber, C.J.†, and Kitajewski, J.† (2014) Notch functions in lymphatic valve formation. Development. 141: 2446-2451. (†Co-senior authorship)
  • *Murtomaki, A., Uh, M.K., Choi, Y.K., Kitajewski, C. Borisenko, V., Kitajewski, J.†, and Shawber, C.J.† (2013) Notch1 functions as a negative-regulator of lymphatic endothelial cell differentiation in the venous endothelium. Development. 140: 2365-2376. (†Co-senior authorship)
  • Shawber, C.J., Funahashi, Y., Francisco, E., Podgrabinska, S., Kitamura, Y., Vorontchikhina, M., Shiraishi, K., Chawengsaksophak, K., Rossant, J., Accili, D., Skobe, M., and Kitajewski, J. (2007) Notch Signaling Alters VEGF Responsiveness in Endothelial Cells by Directly Regulating the Expression of VEGFR-3. Journal Clinic Investigations. 117: 3369-3382.