Carrie Shawber

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Overview

Administrative Titles

  • Assistant Professor of Reproductive Sciences in OB/Gyn & Surgery

Carrie Shawber is an Assistant Professor of Reproductive Sciences in Obstetric & Gynecology and Surgery. Dr. Shawber received her BS in Biology and PhD in Molecular Biology from University of California, Los Angeles. After completing her graduate studies on Mammalian Notch Signaling, Dr. Shawber trained as a postdoctoral research fellow at Weill Cornell Medical College in Cancer Genetics and Epigenetics and Columbia University in Vascular Biology. Her studies of embryonic lymphatic development and lymphatic anomalies have received funding from the Department of Defense, National Cancer Institute, and National Institute of Biomedical Imaging and Bioengineering, as well as private foundations. Dr. Shawber’s laboratory is currently funded by the National Institute of Diabetes and Digestive and Kidney Diseases, the Million Dollar Bike Ride Grant Program, and the Lipedema Foundation.  

Credentials & Experience

Honors & Awards

  • NIH/NIDDK Mentored Research Scientist Development Award, 2006-2010
  • LRF-Andrew Moisoff Young Investigator Poster Award Recognition, Molecular Mechanisms in Lymphatic Function and Disease, Gordon Research Conference, 2004
  • Department of Defense Breast Cancer Postdoctoral Fellowship, 2003-2006
  • NIH/NCI Molecular and Developmental Biology of Cancer Training Grant (Columbia University), 2002-2003
  • NIH, Biotechnology Training Grant (UCLA), 1996-1998
  • Paul Boyer Fellowship, Molecular Biology Institute (UCLA), 1995
  • Second place: Poster Competition, Society for Developmental Biology 54th Annual Symposium, 1995

Research

The Shawber laboratory is interested in understanding developmental and pathological lymphatic vascular biology. We use conditional genetic mouse models to study the role of Notch, MMPs, and RERE in lymphatic endothelial specification, remodeling, and homeostasis with a focus on the digestive track and the skin. Information gained from our murine genetic studies is used to understand human pathological lymphatic disorders and diseases, such as Down syndrome, Turner syndrome, lymphatic malformations, congenital chylothoraxes, and generalized lymphatic anomalies. In collaboration with Dr. June Wu, a Plastic Surgeon at CUMC, we developed a Basic and Translational Vascular Anomalies Research Program in January 2014 with the goals to characterize and identify the genetic and molecular causes of blood and lymphatic vascular anomalies/disorders/diseases, as well as improve diagnosis via new imaging methodologies and identify optimal treatment options for patients.

Research Interests

  • Lymphatic Vascular Development
  • Lymphatic Congenital Defects
  • Vascular Anomalies
  • Notch, MMP

Grants

Notch function in postnatal intestinal and mesenteric lymphatics (NIH/NIDDK), 2017-2022

Identification of the Genetic Causes of Generalized Lymphatic Anomalies (MDBR), 2017

Characterization and Therapeutic Targeting of Lymphatic Dysfunction in Congenital Chylothorax (Irving Institute for Clinical and Translational Research), 2014

Concurrent Ultrasound & Molecular Evaluation of a Lymphatic Malformation Model  (NIH/NIBIB), 2013-2016

Notch Signaling in Lymphangiogenesis (NIH/NCI), 2009-2015

Notch and Insulin Signaling Interactions in Adipogenesis and Angiogenesis (NIH/NIDDK), 2006-2010

NOTCH FUNCTION IN POSTNATAL INTESTINAL AND MESENTERIC LYMPHATICS (Federal Gov)

May 15 2017 - Apr 30 2022

ROLE OF ANGIOGENIC NOTCH IN UTERINE DECIDUALIZATION AND PLACENTATION (Federal Gov)

Apr 1 2016 - Mar 31 2021

IDENTIFICATION AND CHARACTERIZATION OF THE GENETIC CAUSES OF LYMPHATIC ANOMALIES (Federal Gov)

Aug 10 2017 - Jul 31 2019

IDENTIFICATION OF THE GENETIC CAUSES OF GENERALIZED LYMPHATIC ANOMALIES (Private)

Jan 1 2017 - Dec 31 2017

CLIC FUNCTION IN ANGIOGENESIS (Federal Gov)

Dec 20 2013 - Nov 30 2017

NOTCH IN ANGIOGENESIS AND VASCULAR BIOLOGY (Federal Gov)

Jul 17 2012 - Jun 30 2016

CONCURRENT ULTRASOUND & MOLECULAR EVALUATION OF A LYMPHATIC MALFORMATION MODEL (Federal Gov)

Jun 1 2013 - May 31 2016

NOTCH SIGNALING IN LYMPHANGIOGENESIS (Federal Gov)

Jun 1 2009 - Apr 30 2015

Selected Publications

  • Wu, J.K., Hooper, E.D., Laifer-Narin, S.L., Simpson, L.L., Kandel, J.J. and Shawber, C.J. (2016) Initial experience with propranolol treatment of lymphatic anomalies: A Case Series. Pediatrics. 138:e20154545.
  • Shawber, C.J., Lin, L., Gnarra, M., Sauer, M.V., Papaioannou, V.E., Kitajewski, J.K., and Douglas, N.C. (2016) Peri-implantation vasculature and expression of Notch proteins and ligands in the mouse uterus. Vascular Cell. 7:9.
  • Wu, J.K., Kitajewski, C., Reiley, M., Andrews, J.P., Thirumoorthi, A., Wong, A., Keung, C.H., Monteagudo, J., Kitajewski, A., Sastra, S., Behr, G., Kandel, J.J.*, and Shawber, C.J.* (2015) Aberrant Lymphatic endothelial progenitor cells in lymphatic malformation development. PLoS One. 10:e0117352. (*Co-senior Authorship)
  • Kangsamaksin, T., Murtomaki, A., Kofler, N.M., Cuervo, H., Chaudhri, R.A., Tattersall, I.W., Rosenstiel, P.E., Shawber C.J., and Kitajewski, J.  (2015) Notch Decoys that Selectively Block Dll/Notch or Jagged/Notch Disrupt Angiogenesis by Unique Mechanisms to Inhibit Tumor Growth. Cancer Discovery. 5:182-197.
  • Douglas, N.C., Zimmermann, R.C., Tan, Q-K., Sullivan-Pyke, C.S., Sauer, M.V., Kitajewski, J.K., and Shawber, C.J. (2014) VEGFR-1 blockade disrupts peri-implantation decidual macrophage recruitment and angiogenesis. Vascular Cell. 6:16.
  • Murtomaki, A., Uh, M.K., Kitajewski, C., Zhao, J., Nagasaki, T., Shawber, C.J.*, and Kitajewski, J.*  (2014) Notch promotes lymphatic valve maturation. Development. 141: 2446-2451.  (*Co-senior Authorship)
  • Hernandez, S.L., Banerjee, D., Garcia, A., Kangsamakisin, T., Cheng, W., Anastassiou, D., Funahashi, Y., Shawber, C.J., Kitajewski, J.K., Kandel, J.J., and Yamashiro, D.J.  (2013) Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis.  Vascular Cell. 5: 17.
  • Murtomaki, A., Uh, M.K., Choi, Y.K., Kitajewski, C. Borisenko, V., Kitajewski, J.*, and Shawber, C.J.* (2013) Notch1 functions as a negative-regulator of lymphatic endothelial cell differentiation in the venous endothelium. Development. 140: 2365-2376. (*Co-senior Authorship)
  • Funahashi, Y., Shawber, C.J., Sharma, A., Kanamaru, E., Choi, Y.K., and Kitajewski, J., (2011) Notch modulates VEGF action in endothelial cells by inducing matrix metalloprotease activity. Vascular Cell. 3: 2.
  • Nichol, D., Shawber, C., Fitch, M.J., Bambino, K., Sharma, A., Kitajewski, J., and Stuhlmann, H. (2010) Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7. Blood. 116: 6133-6143.
  • Funahashi, Y., Shawber, C.J., Vorontchikhina, M. Sharma, A., Outtz, H.H., and Kitajewski, J. (2010) Notch regulates the angiogenic response via induction of VEGFR-1. J Angiogenesis Res. 2: 3.
  • Funahashi, Y., Hernandez, S.L., Das, I., Ahn, A., Huang, J., Vorontchikhina, M., Sharma, A., Kanamaru, E., Borisenko, V., Desilva, D.M., Suzuki, A., Wang, X., Shawber, C.J., Kandel, J.J., Yamashiro, D.J., and Kitajewski, J. (2008) A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. Cancer Res. 68: 4727-35.
  • Shawber, C.J., Funahashi, Y., Francisco, E., Podgrabinska, S., Kitamura, Y., Vorontchikhina, M., Shiraishi, K., Chawengsaksophak, K., Rossant, J., Accili, D., Skobe, M., and Kitajewski, J. (2007) Notch Signaling Alters VEGF Responsiveness in Endothelial Cells by Directly Regulating the Expression of VEGFR-3.  J Clin Invest. 117: 3369-3382.
  • Shawber, C.J., Das, I., Francisco, E., and Kitajewski, J. (2003) Notch signaling in primary endothelial cells. Ann. N. Y. Acad. Sci. 995: 162-170.
  • Shawber, C.J.*, Nofziger, D.*, Hsieh, J.J.-D., Lindsell, C.E., Bogler, O., Hayward, D., and Weinmaster, G. (1996) Notch signaling inhibits muscle cell differentiation through a CBF-1 independent pathway. Development. 122: 3765-3773. (*Co-first Authorship)
  • Shawber, C., Boulter, J., Lindsell, C.E., and Weinmaster, G. (1996) Jagged2: a Serrate-like gene expressed during rat embryogenesis. Developmental Biology .180: 370-376.
  • Lindsell, C.E., Shawber, C.J., Boulter, J., and Weinmaster, G. (1995) Jagged: A mammalian ligand that activates Notch1. Cell. 80: 909-917.