Tal Korem, PhD
- Assistant Professor of System Biology and Reproductive Sciences (in Obstetrics and Gynecology)
Tal Korem, PhD, is an assistant professor of systems biology and reproductive sciences (in Obstetrics and Gynecology) and a member of Columbia's Program for Mathematical Genomics (PMG). The Korem Lab conducts research aimed at facilitating the downstream development of microbiome-based therapeutics. They use machine learning, network inference and metabolic modelling to obtain a mechanistic understanding of host-microbiome interactions in clinically relevant settings. While the recognition of the microbiome’s importance in human health and disease is constantly growing, and multiple aberrant microbial states have been characterized, they remain poorly understood. In most cases we still do not know what drives, sustains, or modulates these states - let alone how to reverse them. Working at the intersection between computational biology and medicine, the Korem Lab both develops algorithms and computational methods that aim to understand microbial growth, activity, and metabolic production, as well as apply these methodologies as the basis for clinical inquiries in diverse settings, with a special focus on reproductive sciences.
IDENTIFICATION OF GENOMIC AND IMMUNE FACTORS IN HIGH-RISK POPULATIONS FOR PANCREATIC CANCER (Private)
May 10 2019 - May 9 2021
Zeevi, D., Korem, T., Godneva, A. et al. Structural variation in the gut microbiome associates with host health. Nature 568, 43–48 (2019). https://doi.org/10.1038/s41586-019-1065-y
Tal Korem, David Zeevi, Niv Zmora, Omer Weissbrod, Noam Bar, Maya Lotan-Pompan, Tali Avnit-Sagi, Noa Kosower, Gal Malka, Michal Rein, Jotham Suez, Ben Z Goldberg, Adina Weinberger, Avraham A Levy, Eran Elinav, Eran Segal. Bread affects clinical parameters and induces gut microbiome-associated personal glycemic responses. Cell Metabolism 25 (6), 1243-1253 (2017).
David Zeevi, Tal Korem, Niv Zmora, David Israeli, Daphna Rothschild, Adina Weinberger, Orly Ben-Yacov, Dar Lador, Tali Avnit-Sagi, Maya Lotan-Pompan, Jotham Suez, Jemal Ali Mahdi, Elad Matot, Gal Malka, Noa Kosower, Michal Rein, Gili Zilberman-Schapira, Lenka Dohnalov, Meirav Pevsner-Fischer, Rony Bikovsky, Zamir Halpern, Eran Elinav, Eran Segal. Personalized nutrition by prediction of glycemic responses. Cell 163 (5), 1079-1094 (2015)
Tal Korem, David Zeevi, Jotham Suez, Adina Weinberger, Tali Avnit-Sagi, Maya Pompan-Lotan, Elad Matot, Ghil Jona, Alon Harmelin, Nadav Cohen, Alexandra Sirota-Madi, Christoph A Thaiss, Meirav Pevsner-Fischer, Rotem Sorek, Ramnik J Xavier, Eran Elinav, Eran Segal. Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples. Science 349 (6252), 1101-1106 (2015).