Shawber Lab

Location and Contact Information

Department of Obstetrics and Gynecology - Columbia University Medical Center
630 W. 168th Street
PS16-440
New York, NY 10032
United States

Principal Investigators

  • Profile Headshot
    • Assistant Professor of Reproductive Sciences in OB/Gyn & Surgery
Color enhanced cell scan.

The Shawber laboratory is interested in understanding developmental and pathological lymphatic vascular biology. We use conditional genetic mouse models to study the role of Notch, MMPs, and RERE in lymphatic endothelial specification, remodeling, and homeostasis with a focus on the digestive track and the skin. Information gained from our murine genetic studies

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is used to understand human pathological lymphatic disorders and diseases, such as Down syndrome, Turner syndrome, lymphatic malformations, congenital chylothoraxes, and generalized lymphatic anomalies. In collaboration with Dr. June Wu, a Plastic Surgeon at CUMC, we developed a Basic and Translational Vascular Anomalies Research Program in January 2014 with the goals to characterize and identify the genetic and molecular causes of blood and lymphatic vascular anomalies/disorders/diseases, as well as improve diagnosis via new imaging methodologies and identify optimal treatment options for patients.

 

Lab Members

  • Ajit Muley, PhD

    Associate Research Scientist

  • Glicella Salazar-De Simone, PhD

    Postdoctoral Scientist

  • Valeriya Borisenko

    Lab Technician

  • Gillian Hecht

    Lab Technician

  • Joseph McCarron

    Lab Technician

  • Roxane Handel-Orefice, MD

    Research Fellow